De-industrialization is a long-term process. This shift towards a factory-free economy in high income countries has drawn the attention of policy makers in North America and Europe. Some politicians have articulated alarming views, initiating mercantilist or “beggar-thy-neighbor” cost-competitiveness or protectionist policies. Yet companies that concentrate research and design innovations at home but no longer have any factories there may be the norm in the future. The evidence in this book suggests that de-industrialization is a process that happens over time in all countries, even China. One implication is that China-bashing is not likely to provide a solution to these long-term trends. Another implication is that the distinction between manufacturing and services is likely to become increasingly blurry. More manufacturing firms are engaging in services activities, and more wholesale firms are engaging in manufacturing. One optimistic perspective suggests that industrial country firms may be able to exploit the high-value added and skill-intensive activities associated with design and innovation, as well as distribution, which are all components of the global value chain for manufacturing. A less optimistic picture emerges when we turn to an evaluation of the impact of these trends on industrial country labor markets. While over the longer-term economies may adjust to the shift towards a factory-free economy, in the medium term the personal and therefore the political costs are significant. While this ongoing transformation of industrial economies is consistent with the evolution of their comparative advantage, it has significant short-term costs and requires long-term public policies, all the more so as a side-effect of the new organization of the global economy is the growing importance of large, talent-agglomerating cities. Conversely, territories negatively affected by these changes may elect members with more extremist visions, favoring protectionist policies. This is the great challenge for our democracies: to create the policies and political dialogue that will make structural transformations acceptable to citizens.